Gülfem Hatun (Ottoman Turkish: کلفام خاتون‎; c. 1492 - c. 1561) was the Empress consort of Sultan Bayezid II (reign 1481-1512) of the Ottoman Empire.

Gülfem Hatun was born in 1492, and was Albanian by birth. She belonged to Kastrioti family. She married Bayezid in 1507.After his deposition and death in 1512, and Gülfem remained at the Eski Palace, Istanbul. Throughout Suleiman the Magnificent's reign (reign 1520 - 1566), she enjoyed a considerable status within the imperial harem, thus she is supposed by some authors to have been a concubine of Suleyman's or the stewardess of his harem and received 150 aspers a day.

In 1522 she commissioned a fountain in Yenişehir, and in 1524 another fountain in Manisa. In September 1542, she commissioned a soup kitchen in Üsküdar. In March 1543 she established the financial ground work to built a "timber frame mosque" now known as the "Gülfem Hatun Mosque", located near the soup kitchen. According to a local tradition, the mosque was intended for the use of women and opened to men only in recent times. A school is also present near the mosque.

She died in 1561, and was buried in her own mosque.

In the 2003 TV miniseries, Hürrem Sultan, Gülfem Hatun was played by Turkish actress Yasemin Kozanoğlu.

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