Fund for the Replacement of Animals in Medical Experiments
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| Abbreviation | FRAME |
|---|---|
| Formation | 1969 |
| Type | Charity |
| Purpose | Animal welfare |
| Headquarters | Nottingham |
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Region served
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United Kingdom |
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Budget
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£800,805 |
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Staff
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6 |
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Volunteers
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0 |
| Website | http://www.frame.org.uk |
Fund for the Replacement of Animals in Medical Experiments (FRAME) is a charity based in Nottingham, UK. FRAME promotes consideration of the ethical and scientific issues involved in the use of laboratory animals for medical research, and the adoption of the Three Rs strategy of alternatives to animal testing.
The Three Rs (Replacement, Reduction, Refinement) strategy was first suggested by zoologist William Russell and microbiologist Rex Burch, with Replacement being the ultimate goal. FRAME campaigns for the replacement of animal testing methods with alternatives that do not use animals. If there is no valid alternative, FRAME believes the number of animals involved should be reduced as far as possible, and the procedures applied should be refined to minimise potential pain and distress.
The FRAME research programme involves both office-based and laboratory-based research. Staff at the Nottingham city offices and the FRAME Alternatives Laboratory at The University of Nottingham Medical School work to find ways in which the use of laboratory animals can be replaced with procedures which employ alternative methods such as cells in culture, computer-based approaches and ethical studies on human cells, tissues and volunteers. Research funded by FRAME has contributed to reducing the number of animals used in research and testing.
FRAME was founded by Dorothy Hegarty who was introduced to the Three Rs by the biologist Charles Foister. It was registered as a UK charity in 1969. FRAME had a starting fund of £100 and was first based in a room in the Hegarty house in Wimbledon, London. Eventually, money from donations provided a salary for a secretary. Soon, enough funds were available for FRAME to rent a shop in Worple Rd, Raynes Park, London where it was based for almost a decade.
1978 - FRAME held a symposium at the Royal Society on the Use of Alternatives in Drug Research.
1981 - Michael Balls became Chairman of the FRAME trustees and FRAME moved to Nottingham. Soon after, a research programme and links with the University of Nottingham were established.
1979 - The FRAME Toxicity Committee presented its first report on alternatives to using animals for toxicity testing at the Animals and Alternatives in Toxicity Testing conference, organised by FRAME, and held at the Royal Society in 1982.
1983 - ATLA (Alternatives to Laboratory Animals) relaunched With the help of funding from the Maurice Laing Foundation. ATLA, formerly a pamphlet style publication, was relaunched as a peer-reviewed international scientific journal.
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