Friedrich Wilhelm, Prince of Hohenzollern (German: Friedrich Wilhelm Ferdinand Joseph Maria Manuel Georg Meinrad Fidelis Benedikt Michael Hubert Fürst von Hohenzollern; February 3, 1924– September 16, 2010) was the head of the Princely House of Hohenzollern.

Friedrich Wilhelm was born in Schloss Umkirch. He was the eldest son of Friedrich, Prince of Hohenzollern (1891–1965) and his wife, Princess Margarete Karola of Saxony (1900–1962), the daughter of the last King of Saxony Frederick Augustus III. He became the head of the House of Hohenzollern on the February 6, 1965 following the death of his father Prince Friedrich, and remained so until his death on September 16, 2010.

According to the Romanian succession laws of the kingdom's last democratic Constitution of 1923, upon the demise of King Michael, provided he dies without any male children as is now likely, Friedrich Wilhelm's descendants have a claim to the Romanian throne (see "Line of succession to the Romanian throne"). In 2006, the prince publicly stated that the Hohenzollerns had 'no interest in the Romanian throne', and King Michael proclaimed an updated line of succession, with equal primogeniture, designating his eldest daughter 'Crown Princess'.

Friedrich Wilhelm married Princess Margarita of Leiningen (1932–1996) on February 3, 1951. She was a child of Karl, 6th Prince of Leiningen, and his wife, Grand Duchess Maria Kirillovna of Russia.

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