Frederick Creek is a stream in Oregon County of the Ozarks of southern Missouri. It is a tributary of Eleven Point River.
The stream headwaters are at 36°42′39″N 91°29′05″W / 36.71083°N 91.48472°W and the confluence with the Eleven Point is at 36°33′49″N 91°10′40″W / 36.56361°N 91.17778°WCoordinates: 36°33′49″N 91°10′40″W / 36.56361°N 91.17778°W.
Frederick Creek, also historically called "Frederick's Fork", has the name of an early settler.