Franz Karl Naegele (7 December 1778 – 21 January 1851) was a German obstetrician born in Düsseldorf. His son, Hermann Franz Naegele (1801-1851), was also a noted obstetrician.
He earned his medical degree from the University of Bamberg, afterwards opening a medical practice in Barmen. In 1807 he became an associate professor at the University of Heidelberg, where in 1810 he was appointed a full professor of obstetrics.
He is remembered for "Naegele's rule", a standard method of calculating the due date for a pregnancy. His name is also lent to "Naegele obliquity", also known as an anterior asynclytism.