Francisco de los Cobos y Molina (c. 1477 – 10 May 1547) was the secretary of State and Comendador for the kingdom of Castile under the rule of the Emperor Charles I of Spain.
He was born in Úbeda ca. 1477 and died on 10 May 1547 in the same city. He was born to the aristocratic, though economically disadvantaged family of Don Pedro Rodríguez de los Cobos, he was the son of don Diego de los Cobos, regent of Ubeda, and Catalina de Molina. In 1522, he married the fourteen-year-old María de Mendoza y Sarmiento, daughter of Juan Hurtado de Mendoza y María de Sarmiento, 6th Countess of Ribadavia. His titles would be inherited by his male son Diego de los Cobos y Hurtado de Mendoza, (circa 1523 – 1575), who was subsequently awarded the title of 1st Marquis of Camarasa, together with his wife, by king Charles I of Spain, a.k.a. Holy Roman Emperor Charles V on 18 February 1543.
His daughter, sister of the 1st Marquis of Camarasa, Diego, is usually known as Maria Sarmiento de Mendoza, as sometimes Spanish Nobility females took as their first family name their mother family name. She married at Valladolid on 30 November 1538, Gonzalo II Fernández de Córdoba, Governor of the Duchy of Milan, 1558–1560 and 1563–1564, a Knight of the Order of the Golden Fleece since 1555, living in Italy when her husband was there a Governor and spending considerable amounts of money, no issue.
In 2008, this title was held by the duke of Segorbe, Ignacio Medina Fernández de Córdoba y Fernández de Henestrosa.
His career benefited from the help aforded by his uncle, Diego Vela Allide, treasurer and secretary of queen Isabella I of Castile. Later, by 1503, he worked as a scribe under the dean of the Queen's secretaries, Hernando de Zafra. In 1507, upon Zafra's death, he became first Treasurer of Granada, and then Regent for Úbeda the next year. These positions were entitled to collect tribute and payments to the crown.