Francisco Guerrero y Palomares (1811 – 13 July 1851) was the Mexican Alcalde of Yerba Buena (later renamed San Francisco) in Mexican Alta California Territory, in 1836 and in 1839.
Guerrero was born in Tepic, New Spain (colonial México). He came to Alta California with the Hijar-Padres Colony in 1834, and settled in Yerba Buena (San Francisco). He was married to Josefa De Haro (daughter of Alcalde Francisco De Haro), and had five sons.
He was the third Alcalde of Yerba Buena in 1836. Guerrero served again as the sixth Alcalde in 1839.
In 1844 he was granted Rancho Corral de Tierra, located in present day San Mateo County, California. A section of the land grant is now a part of the Golden Gate National Recreation Area.
Francisco Guerrero was murdered in 1851 by Francis LeBras, in American San Francisco. He is buried at the Mission Dolores cemetery in the City.
Guerrero Street in San Francisco is named in his honor.