Francisco Castellón Sanabria (1815 – 8 September 1855) was president of "Democratic" Nicaragua from 1854-1855 during the Granada-León civil war.
Castellón was a lawyer from León. He was prime minister (ministro general) under Patricio Rivas, but was removed in 1841 by Pablo Buitrago, and reappointed in 1843 by Manuel Perez. In 1844 he served as Nicaragua's minister to England and later as Nicaragua's minister to France. He was again a government minister under José Laureano Pineda 1851-1853.
In 1853, the Liberal Party candidate Francisco Castellón from León and the Conservative Party candidate Fruto Chamorro of Granada both ran for the position of Supreme Director of Nicaragua. Chamorro won, and there were claims of election fraud. Chamorro immediately transferred the government headquarters from Managua to Granada, the Conservative stronghold. He then convened a Constitutional Assembly on 20 January 1854, to promulgate a new Constitution during the absence of the majority of the Liberal Party representatives. The rigged election and Chamorro's subsequent actions including the promulgation of the Constitution of 1854, considered to be badly flawed by the Liberals, provoked prominent Liberals - including Francisco Castellón, Máximo Jerez, and José María Valle - to establish a separate government which they did in León. Castellón was proclaimed president on 11 June 1854.
Although his forces were initially militarily successful against Chamorro, a long unsuccessful siege of Granada was followed by the loss of Managua, Masaya and Rivas. This lead Castellón to hire William Walker and his mercenaries, who arrived in June 1855. Castellón died of cholera 8 September 1855 and was succeeded as "Democratic" president by Nazario Escoto.