Francisca Pizarro Yupanqui (1534-1598) was the daughter of Inés Yupanqui and Francisco Pizarro; she was also the niece and wife of Hernando Pizarro. Francisca was recognized as a legitimate heir of Francisco Pizarro by Emperor Charles V in a royal decree on October 12, 1537.
She and her uncle/husband ordered the building of the Palace of the conquest in Trujillo, Spain; it features busts of them and others.
She had five children.