Francis Wise (3 June 1695 – 5 October 1767) was an academic, archivist and antiquarian at the University of Oxford.
Francis Wise was born in Oxford (where his father, also called Francis, was a mercer) on 3 June 1695. After being educated at New College School he matriculated at the University of Oxford as a member of Trinity College in 1711. He became a fellow of the college in 1718 and was ordained deacon and priest in 1721. Within the university, he served as under-keeper of the Bodleian Library from 1719, trying but failing to become Bodley's Librarian in 1729 and President of Trinity College in 1731. He did, however, win the election for the position of Keeper of the Archives in 1726, in which he was the only Whig candidate. He carried out no new work with the archives, unlike his predecessors. His final success was to become the first librarian of the Radcliffe Library in 1748 – a sinecure post, since it was an institution that at the outset had "few books and even fewer readers".
His parish appointments were aided by Francis North, 1st Earl of Guilford, the father of one of his pupils: Wise became curate of Wroxton, Oxfordshire (1723), to which were later added the parish of Harlow, Essex (briefly, in 1726, before his election as Keeper of the Archives) and the parish of Elsfield near Oxford (1726 onwards). Trinity College appointed him rector of Rotherfield Greys in 1745, and he resigned his fellowship at this time. He improved the house and garden in Elsfield, and was visited there by the writer and lexicographer Samuel Johnson and the poet and critic Thomas Warton in 1754. Wise helped to ensure that Johnson was awarded an honorary degree by the university later that year.