Francis T. Nicholls High School and later Frederick Douglass High School are the former names of a high school at 3820 St. Claude Avenue in the Ninth Ward of New Orleans, Louisiana. Initially named for Francis T. Nicholls, a former Confederate general, governor of Louisiana, and Chief Justice of the Louisiana Supreme Court, the school opened as a segregated white institution on January 29, 1940. During the middle 1990s, having since long been desegregated, Nicholls High School was renamed in honor of the African-American abolitionist Frederick Douglass of Maryland. The school has since been again reorganized and renamed. The Douglass building is now home to a public charter school known as KIPP Renaissance High School which earned an "A" letter grade from the Louisiana Department of Education in 2016.
From 1880 to 1939, another school, McDonogh No. 12, was located at the site on St. Claude Avenue. That school was demolished to make way for Nicholls High School. The land on which Nicholls and Frederick Douglass High School stood was originally part of the Louis Barthelemy Macarty plantation. After Macarty died in 1846, philanthropist John McDonogh purchased the property and donated it to the City of New Orleans. McDonough also donated other properties and money for use of New Orleans public schools.