Sir Francis Fortescue (ca. 1563–1624), KB was an English politician.
Francis was the eldest surviving son of John Fortescue I and his wife, Cecily Ashfield. His brothers were William Fortescue and Thomas Fortescue II. In 1589, he married Grace Manners. They had at least one child, his heir, John.
In 1600, he became the Custos Rotulorum of Buckinghamshire and in 1608 High Sheriff of Buckinghamshire. In 1589, 1593 and 1597 he was MP for Buckingham, and in 1601 MP for Buckinghamshire.