Frances MacDonald (1873–1921) was a Scottish artist whose design work was a prominent feature of the "Glasgow Style" during the 1890s.
The sister of the better known artist Margaret MacDonald, she was born near at Tipton, near Wolverhampton, and moved to Glasgow with her family in 1890. Both sisters enrolled in painting classes at the Glasgow School of Art in 1891, where they met the architect Charles Rennie Mackintosh and artist Herbert MacNair. Frances went on to marry MacNair, and Margaret married Mackintosh. All four later became the loose collective of the Glasgow School known as "The Four".
In the mid-1890s the sisters left the School to set up an independent studio together. They collaborated on graphics, textile designs, book illustrations and metalwork, developing a distinctive style influenced by mysticism, symbolism and Celtic imagery. Frances also produced a wide variety of other artistic work, including embroidery, gesso panels and water colour paintings. Like her sister, she was influenced by the work of William Blake and Aubrey Beardsley and this is reflected in her use of elongated figures and linear elements. Around this time Frances and her sister Margaret became members of the Glasgow Girls, which comprised women artists and designers. The sisters exhibited in London, Liverpool and Venice.