Born in Dallas, Texas, Fran Harris is the fourth of five children; she has three brothers and a sister. She started playing basketball when she was a sophomore at South Oak Cliff High School and played on the on JV and varsity teams her first year. She then helped the team to a 40-0 season and State Championship. She moved on to the University of Texas at Austin where she had a standout basketball career and earned bachelor's degrees and master's degrees in journalism.

Harris was a player for The University of Texas at Austin from 1982 to 1986. She led her team to its first and only NCAA Championship title, to date in 1986 with the first perfect season in women's NCAA history. The team went 34-0. Harris was the leading scorer three years in a row and was the team captain in 1986. She was named to the Southwest Conference All-Decade Team, SWC Player of the Year and was two-time team MVP, selected by teammates. Harris was an outside shooter who finished her career as the University's fourth all-time leading scorer with 1,798 points.

Harris played for USA Basketball as part of the 1985 USA National Jones Cup Team that captured Gold for the second year in a row, World Championship Team in 1986 that won Gold, USA Women's Pan American Team in 1987 that won a gold medal in Indianapolis, Indiana and was an Olympic Team Alternate in 1988.

After college, Harris went to play professional basketball in Italy and Switzerland. She later played for two years in the WNBA. In the league's inaugural season, she was a member of the Houston Comets. She started one game for the Comets but played in 25 games coming off he bench, scoring a total of 104 points on the season as the Comets won the first-ever WNBA Championship. The next season, she was a starter for the Utah Starzz. At the end of the season she was waived from the team's roster, and chose to retire and begin her career in broadcasting with TV partner, Lifetime.

Harris hosted the transformational makeover show, Home Rules on HGTV, in which Harris helped redesign the interiors of people's homes.

Harris has been coaching since she was a teenager and has been a fitness advocate since college. Since retiring from the WNBA, Harris has appeared as a fitness and life coach on many television shows. She produced and hosted her own reality show, America's Fitness Show, which aired in Austin, Texas.

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