Florence Avenue is a major east–west street in central Los Angeles County and South Los Angeles, in Southern California.
It starts off as Mills Road at Janine Drive in Whittier. At Telegraph Road, it changes to Florence. West of La Cienega Boulevard, it swerves into Aviation Boulevard, which is a north–south street, in the City of Inglewood.
Florence Avenue runs through the cities of Inglewood, Los Angeles, Huntington Park (where it intersects Pacific Boulevard), Bell, Bell Gardens, Downey, Santa Fe Springs, and unincorporated Los Angeles County bordering the City of Whittier.
Florence Avenue also crosses under Harbor Freeway (Interstate 110), Long Beach Freeway (Interstate 710), San Gabriel River Freeway (Interstate 605), and Santa Ana Freeway (Interstate 5).
Metro Local lines 111 and 120 run through Florence Avenue; the former runs through most of Florence starting at Studebaker Road and the latter east of Studebaker Road.
The Metro Blue Line light rail serves the Florence Metro station, at Graham Avenue and Florence Avenue in the unincorporated community of Florence.