Flat River is a stream in St. Francois County, Missouri. It is a tributary of the Big River.
The stream source is at: 37°46′14″N 90°35′20″W / 37.77056°N 90.58889°W and the confluence is at: 37°53′31″N 90°29′59″W / 37.89194°N 90.49972°WCoordinates: 37°53′31″N 90°29′59″W / 37.89194°N 90.49972°W.
Flat River was so named on account of its flat banks. A variant name was "River la Platte".