Fispemifene

Fispemifene
Identifiers

IUPAC name 2-(2-(4-((1Z)-4-Chloro-1,2-diphenylbut-1-enyl)phenoxy)ethoxy)ethanol
Synonyms	HM-101
CAS Number	341524-89-8
PubChem CID	9954033
ChemSpider	8129643
UNII	3VZ2833V08
KEGG	D10008
ChEMBL	CHEMBL2107341
Chemical and physical data
Formula	C₂₆H₂₇ClO₃
Molar mass	422.9493 g/mol
3D model (Jmol)	Interactive image
SMILES C1=CC=C(C=C1)/C(=C(/C2=CC=CC=C2)\C3=CC=C(C=C3)OCCOCCO)/CCCl
InChI InChI=1S/C26H27ClO3/c27-16-15-25(21-7-3-1-4-8-21)26(22-9-5-2-6-10-22)23-11-13-24(14-12-23)30-20-19-29-18-17-28/h1-14,28H,15-20H2/b26-25- Key:NKZTZAQIKKGTDB-QPLCGJKRSA-N

Fispemifene (INN, USAN) (developmental code name HM-101) is a non-steroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that was developed for the treatment of male hypogonadism but was abandoned and never marketed. It reached phase II clinical trials for this indication before development was terminated in March 2016. The drug failed to achieve statistical significance on key effectiveness endpoints in clinical trials and was discontinued by its developer for strategic reasons.