Fengabine

Fengabine
Clinical data

Routes of administration	Oral
ATC code	none
Legal status
Legal status	Uncontrolled
Identifiers
IUPAC name (6Z)-6-[butylamino-(2-chlorophenyl)methylene]-4-chloro-cyclohexa-2,4-dien-1-one
CAS Number	80018-06-0
PubChem CID	5362066
ChemSpider	4514924
UNII	YQG0NJI5A7
KEGG	D04149
Chemical and physical data
Formula	C₁₇H₁₇Cl₂NO
Molar mass	322.23 g/mol

Fengabine (SL-79,229) is a drug which was investigated as an antidepressant but was never marketed. Its mechanism of action is unknown, but its antidepressant effects are reversed by GABA_A receptor antagonists like bicuculline and it has hence been labeled as GABAergic; however, it does not actually bind to GABA receptors, nor does it inhibit GABA-T. In clinical trials, fengabine's efficacy was comparable to that of the tricyclic antidepressants, but with a more rapid onset of action and much less side effects. Notably, fengabine lacks any sedative effects.