Feathery degeneration

In histopathology, feathery degeneration, formally feathery degeneration of hepatocytes, is a form of liver parenchymal cell (i.e. ) death associated with cholestasis.

Cells undergoing this form of cell death have a flocculant appearing cytoplasm, and are larger than normal hepatocytes.

Feathery degeneration is somewhat similar in appearance to ballooning degeneration, which is due to other causes (e.g. alcohol, obesity); it also has cytoplasmic clearing and cell swelling.

Feathery degeneration. H&E stain.

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