Fausto Poli (17 February 1581 – 7 October 1653) was a Roman Catholic prelate and Cardinal.
Born in Usigni in Umbria, as a young man he went to Rome and was soon noticed by Maffeo Barberini, a cleric of the Apostolic Chamber and a fellow Umbrian from nearby Spoleto, soon to become Pope under the name of Urban VIII. In 1632 he was made Majordomo and Prefect of the Lateran palace, in which posts he was responsible for supervising church and court ceremonies. In 1633 he was consecrated titular archbishop of Amasia in partibus.
As private secretary to Pope Urban, among his most valuable services was that of purchasing old works of art, or commissioning new works, for that inveterate collector; among the artists he encouraged was Claude Lorrain. He was rewarded toward the end of Urban's pontificate by being raised to the purple as Cardinal-Priest of San Crisogono on 31 August 1643. He was appointed Bishop of Orvieto in 1644.
He participated in the Papal conclave of 1644 which elected Urban's successor, Pope Innocent X.
Throughout his life, he remained very devoted to his home town and region. In addition to beautifying Usigni, he was instrumental in developing iron mines in the area, and he was also so greatly devoted to Rita of Cascia (beatified by Urban in 1627), adorning her church in that town and promoting her cult, that he is often considered to have been the main force in establishing her present cult and popularity. The second edition (1652) of Girolamo de Ghetti's Breve Racconto della Vita e Miracoli della B. Rita da Cascia is dedicated to him.
Poli died in Orvieto in 1653; he was buried according to his wishes in the Chapel of the Guardian Angel in his titular church of San Crisogono.