"Family Affair" is a song by American singer Mary J. Blige. It was written by Blige, her brother Bruce Miller, Camara Kambon, Michael Elizondo, and Dr. Dre for her fifth studio album No More Drama (2001), while production was overseen by the latter. "Family Affair" is a pumping dance-pop song that incorporates elements of hip hop and R&B. The music for the track was originally created in a jam session between Dre and musicians Mel-Man, Camara Kambon, Mike Elizondo and Scott Storch. Later, Blige heard the song that her brother Bruce Miller, Asiah the Continent and Luchi Lodge created the lyrics and melody to and decided on recording her vocals. On the single cover, Dre is seen in the shadows, highlighting his role on the track.

The single topped the Billboard Hot 100 for six weeks starting from November 3, 2001, ending a ten-week lockup of the top two positions on the chart by Alicia Keys' "Fallin'" and Jennifer Lopez's "I'm Real (Murder Remix)", which combined have spent the previous eleven weeks atop the chart. It was Blige's first Hot 100 number-one single. In 2008, for Billboard magazine's 50th Anniversary, "Family Affair" was listed as the 79th-biggest single on the Billboard Hot 100 All-Time Top Songs. while at the end of 2009 was named the 12th most successful song from 2000 to 2009, on the Billboard Hot 100 Songs of the Decade.Rolling Stone ranked it number ninety-five on their list of 100 Best Songs of the 2000s decade. The song was also responsible for the brief comeback of a new form of hip hop soul, a genre that she pioneered in the early 1990s.

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