Evelyn M. Witkin

Evelyn M. Witkin
Evelyn M. Witkin (interviewed in PLOS Genetics 2012)
Born	(1921-03-09) March 9, 1921 (age 96) New York City
Institutions	Columbia University New York University Rutgers University
Alma mater	Columbia University (Ph.D)
Thesis	Genetics of Resistance to Radiation in Escherichia Coli (1947)
Known for	Work on DNA mutagenesis and DNA repair
Notable awards	Member of National Academy of Sciences Thomas Hunt Morgan Medal(2000) National Medal of Science(2002) Lasker Award for Basic Medical Research(2015)

Evelyn M. Witkin, born Evelyn Maisel (born March 9, 1921) is a United States geneticist who was awarded the National Medal of Science for her work on DNA mutagenesis and DNA repair.

In 1944, Witkin spent the summer at Cold Spring Harbor Laboratory (CSHL). During her stay she isolated a UV radiation-resistant mutant of E. coli; this was the first time mutations conferring UV radiation-resistance were isolated. She returned to CSHL in 1945 and stayed there to complete her PhD research; her degree was conferred in 1947 and was employed by the Carnegie Institution to continue work at CSHL until 1955. Witkin then worked at the State University of New York's Downstate Medical Center in Brooklyn until 1971. Witkin was appointed Professor of Biological Sciences at Douglass College, Rutgers University in 1971 and was named Professor of Genetics in 1979, and then moved to the Waksman Institute at Rutgers in 1983.

Witkin's research since the completion of her PhD was based on DNA mutagenesis, her mutagenesis work led to her work on DNA repair. By characterizing the phenotypes of mutagenised E. coli, she and colleague Miroslav Radman (at the time a post doctoral student at Harvard) detailed the SOS response to UV radiation in bacteria in the early 1970s. She continued to work on the mechanism of the SOS response until she retired in 1991. The SOS response to DNA damage was a seminal discovery because it was the first coordinated stress response to be elucidated.

Witkin was elected as a member of the National Academy of Sciences in 1977, at the time she was one of the few women elected to the Academy; a Fellow of the American Academy of Arts and Sciences (1978), a Fellow of the American Association for the Advancement of Science (1980); and a Fellow of the American Academy of Microbiology. She was awarded the 2000 Thomas Hunt Morgan Medal and her contributions to science have been recognized by the United States government as she was awarded the National Medal of Science in 2002;