Eugène-Louis Lequesne (or Le Quesne) (15 February 1815 – 3 June 1887) was a French sculptor.
Lequesne was born and died in Paris. In 1841, he entered the École nationale des beaux-arts, in James Pradier's workshop. In 1843, he won the second Prix de Rome, and in 1844 the first prize, with a plaster bas-relief entitled Pyrrhus tuant Priam. He lived at the Académie de France à Rome from 1844 to 1849, alongside Jean-Louis Charles Garnier. In 1855, he was awarded the Great Prize for sculpture at the Exposition Universelle, and received the Légion d'honneur.