Eudoxia of Moscow (Russian: Евдокия Дмитриевна, Yevdokia Dmitriyevna)—monastic name Euphrosyne— (? – 1407) was a Grand Duchess of Muscovy and wife of Dmitry Donskoy.
Eudoxia was a daughter of Dmitry Konstantinovich, Grand Prince of Nizhny Novgorod and Vasilisa of Rostov.
Her maternal grandparents were Konstantin Vasilievich, Prince of Rostov and Maria of Moscow.
Maria was a daughter of Ivan I of Moscow and his first wife Yelena.
On 18 January 1367, Eudoxia married Grand Prince Dmitry Donskoy. In 1382, she stayed in Moscow in the absence of her husband, while the army of khan Tokhtamysh was approaching the capital. After the birth of her son Andrey Dmitriyevich, she attempted to leave Moscow, but was detained by the Muscovites, who agreed to let her go only after long negotiations.
After her husband's death, Eudoxia became known for her piety; legend has it that she possessed the gift of healing. In 1393, she founded the Church of the Nativity of the Theotokos (Церковь Рождества Богородицы), the oldest surviving building in Moscow. The church was dedicated to the Virgin's Nativity, because on this feast her husband defeated the Tatars in the Battle of Kulikovo.
Four years later, Eudoxia established the Ascension Monastery next to the Frolovskaya (Spasskaya) Tower of the Moscow Kremlin. Later in her life, Eudoxia Dmitriyevna took the veil at the Ascension Monastery under the name of Yefrosiniya (Euphrosyne) and remained there until her death in 1407.