Ethchlorvynol
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| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
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Oral |
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| Protein binding | 35–50% |
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| ECHA InfoCard | 100.239.078 |
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| Formula | C7H9ClO |
| Molar mass | 144.598 g/mol |
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Ethchlorvynol/ˌɛθklɔːrˈvaɪnɒl/ is a GABA-ergic sedative and hypnotic/soporific medication developed by Pfizer in the 1950s. In the United States it was sold by Abbott Laboratories under the tradename Placidyl. Placidyl was available in 200 mg., 500 mg., and 750 mg. strength capsules. While the 500 mg. and 750 mg. strength capsules were for use in reducing sleep latency, the 200 mg. strength capsules were intended to be used to re-induce sleep in case of early awakening. Abbott discontinued production in 1999, after which Placidyl was available for about a year in the United States. Although, theoretically, ethchlorvynol could be manufactured for sale in the United States by another pharmaceutical company (subject to FDA approval of such manufacture), no pharmaceutical company has chosen to do so. Individuals with a valid prescription for the substance may legally transport a reasonable amount of ethclorvynol with them into the United States.
Ethchlorvynol was used to treat insomnia, but prescriptions for the drug had fallen significantly by 1990, as other hypnotics that were considered safer (i.e., less likely to result in overdose) became much more common. It is no longer prescribed in the United States due to unavailability, but it is still available in some countries and would still be considered legal to possess and use with a valid prescription.
Along with expected sedative effects of relaxation and drowsiness, adverse reactions to ethchlorvynol include skin rash, faintness, restlessness and euphoria. Early adjustment side effects may include nausea and vomiting, numbness, blurred vision, stomach pains and temporary dizziness. There are no specific antidotes available for ethchlorvynol, and treatment is supportive with protocols resembling those for the treatment of barbiturate overdose. Overdose may be marked by a variety of symptoms, including confusion, fever, peripheral numbness and weakness, reduced coordination and muscle control, slurred speech, reduced heartbeat, respiratory depression, and in extreme overdoses, coma and death.
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