Erythema multiforme major

Erythema multiforme majus

Micrograph of confluent epidermal necrosis. H&E stain.
Classification and external resources
ICD-9-CM	695.12
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Erythema multiforme major (also known as "Erythema multiforme majus") is a form of rash with skin loss or epidermal detachment.

The term "Erythema multiforme majus" is sometimes used to imply a bullous (blistering) presentation.

According to some sources, there are two conditions included on a spectrum of this same disease process:

In this view, EM major, SJS and TEN are considered a single condition, distinguished by degree of epidermal detachment.

However, a consensus classification separates erythema multiforme minor, erythema multiforme major, and SJS/TEN as three separate entities.

5. Orphanet Journal of Rare Diseases 2010, 5:39 doi:10.1186/1750-1172-5-39