Edward Lewknor (c.1517–1556) was the representative of a branch of a prominent Sussex family, in an armigerous line descending in the distaff side from the Camoys barony. Having attained standing as a member of parliament and (reportedly) a position of service in the royal household, his career was ended abruptly by his involvement in Henry Dudley's conspiracy against Queen Mary I, and his consequent attainder. His children were restored in blood by Queen Elizabeth I.
Edward Lewknor was the son of Edward Lewknor (died 1528) of Kingston Buci, Sussex, and his wife Margaret Copley, daughter of Roger Copley of London and Roffey (in Horsham, Sussex) by his wife Anne, second daughter and coheiress of Sir Thomas Hoo, Baron Hoo and Hastings. Margaret Copley's sister Eleanor was the third wife of Thomas West, 8th Baron De La Warr, who acted as feoffee for Edward's grandfather in securing the descent and uses of his estates according to the terms of his will. Edward's father had a younger half-brother Richard Lewknor and three half-sisters, whose mother Anne Everard (died 1538) remarried to Sir Edward Echingham of Barsham, Suffolk (died 1527).
His grandfather, also Edward (died 1522), was the son and heir of Nicholas Lewknor of Kingston Buci (youngest son of Sir Thomas Lewknor of Horsted Keynes) and his wife Elizabeth (Isabella) Radmylde. Elizabeth and her sister Margaret Radmylde became the coheirs of their nephew William Radmylde, who died without issue. Their mother Margaret Camoys (born c. 1402), first wife of Ralph Radmylde, was granddaughter of Thomas de Camoys, 1st Baron Camoys (died 1421), and (with her sister Alianora) coheir to her brother Hugh Camoys, 2nd Lord Camoys. Alianora married Sir Roger Lewknor of Broadhurst, elder half-brother of Nicholas Lewknor. Hugh died in 1426, when the title went into abeyance until 1839. It was then resurrected in Thomas Stonor, 3rd Baron Camoys, descendant and heir of Elizabeth Radmylde's sister Margaret, who married John Goring.