Ecological study

Ecological studies are studies of risk-modifying factors on health or other outcomes based on populations defined either geographically or temporally. Both risk-modifying factors and outcomes are averaged for the populations in each geographical or temporal unit and then compared using standard statistical methods.

Ecological studies have often found links between risk-modifying factors and health outcomes well in advance of other epidemiological or laboratory approaches.

The study by John Snow regarding a cholera outbreak in London is considered the first ecological study to solve a health issue. He used a map of deaths from cholera to determine that the source of the cholera was a pump on Broad Street. He had the pump handle removed in 1854 and people stopped dying there. It was only when Robert Koch discovered bacteria years later that the mechanism of cholera transmission was understood.

Dietary risk factors for cancer have also been studied using both geographical and temporal ecological studies. Multi-country ecological studies of cancer incidence and mortality rates with respect to national diets have shown that some dietary factors such as animal products (meat, milk, fish and eggs), added sweeteners/sugar, and some fats appear to be risk factors for many types of cancer, while cereals/grains and vegetable products as a whole appear to be risk reduction factors for many types of cancer. Temporal changes in Japan in the types of cancer common in Western developed countries have been linked to the nutrition transition to the Western diet.

An important advancement in the understanding of risk-modifying factors for cancer was made by examining maps of cancer mortality rates. The map of colon cancer mortality rates in the United States was used by the brothers Cedric and Frank C. Garland to propose the hypothesis that solar ultraviolet B (UVB) radiation, through vitamin D production, reduced the risk of cancer (the UVB-vitamin D-cancer hypothesis). Since then many ecological studies have been performed relating the reduction of incidence or mortality rates of over 20 types of cancer to higher solar UVB doses.

Links between diet and Alzheimer’s disease have been studied using both geographical and temporal ecological studies. The first paper linking diet to risk of Alzheimer’s disease was a multi-country ecological study published in 1997. It used prevalence of Alzheimer’s disease in 11 countries along with dietary supply factors, finding that total fat and total energy (caloric) supply were strongly correlated with prevalence, while fish and cereals/grains were inversely correlated (i.e., protective). Diet is now considered an important risk-modifying factor for Alzheimer’s disease. Recently it was reported that the rapid rise of Alzheimer’s disease in Japan between 1985 and 2007 was likely due to the nutrition transition from the traditional Japanese diet to the Western diet.

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