Ecdysone receptor
| Ecdysone receptor protein | |
|---|---|
Crystallographic structure of the ligand binding domain of the ecdysone receptor (rainbow color, N-terminus = blue, C-terminus = red) from Heliothis virescens complexed with ponasterone A (space-filling model, carbon = white, oxygen = red).
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| Identifiers | |
| Organism | |
| Symbol | EcR |
| Alt. symbols | EcRH, NR1H1 |
| Entrez | 35540 |
| PDB | 1R0O More structures |
| RefSeq (mRNA) | NM_165461 |
| RefSeq (Prot) | NP_724456 |
| UniProt | P34021 |
| Other data | |
| Chromosome | 2R: 1.97 - 2.07 Mb |
| Ultraspiracle protein | |
|---|---|
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| Identifiers | |
| Organism | |
| Symbol | USP |
| Alt. symbols | Cf1, NR2B4 |
| Entrez | 31165 |
| PDB | 1HG4 More structures |
| RefSeq (mRNA) | NM_057433 |
| RefSeq (Prot) | NP_476781 |
| UniProt | P20153 |
| Other data | |
| Chromosome | X: 1.93 - 1.94 Mb |
The ecdysone receptor is a nuclear receptor found in arthropods, where it controls development and contributes to other processes such as reproduction. The receptor is a non-covalent heterodimer of two proteins, the EcR protein and ultraspiracle protein (USP). It binds to and is activated by ecdysteroids. Insect ecdysone receptors are currently better characterized than those from other arthropods, and mimics of ecdysteroids are used commercially as caterpillar-selective insecticides.
Pulses of 20-hydroxyecdysone occur during insect development, whereupon this hormone binds to the ecdysone receptor, a ligand-activated transcription factor found in the nuclei of insect cells. This in turn leads to the activation of many other genes, as evidenced by puffing of polytene chromosomes at over a hundred sites. Ultimately the activation cascade causes physiological changes that result in ecdysis (moulting).
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