Earth orbit rendezvous (EOR) is a potential methodology for conducting round trip human flights to the Moon, involving the use of space rendezvous to assemble, and possibly fuel, components of a translunar vehicle in low Earth orbit. It was considered and ultimately rejected in favor of lunar orbit rendezvous (LOR) for NASA's Apollo Program of the 1960s and 1970s. Three decades later, it was planned to be used for Project Constellation, until that program’s cancellation in October 2010.
The Agena target vehicle was used for testing Earth orbit rendezvous in the NASA Gemini Program. Gemini 6 and Gemini 7 rendezvoused in orbit in 1965, but without Agena. Next, Gemini 8 successfully docked March 16, 1966 with the Agena. The Agena-Gemini rendezvous also achieved many other tasks in later Gemini launches.
The EOR proposal for Apollo consisted of using a series of small rockets half the size of a Saturn V to put different components of a spacecraft to go to the Moon in orbit around the Earth, then assemble them in orbit. Experiments of Project Gemini involving docking with the Agena target vehicle were designed partly to test the feasibility of this program.
In the end, NASA employed the Lunar Orbit Rendezvous for the Apollo Program: a Saturn V would simultaneously lift both the Apollo Command and Lunar Modules into low Earth orbit, and then the Saturn V third stage would fire again (Trans-lunar injection) to send both spacecraft to the Moon.