E951

Aspartame

Names
IUPAC name Methyl L-α-aspartyl-L-phenylalaninate
Other names N-(L-α-Aspartyl)-L-phenylalanine, 1-methyl ester
Identifiers
CAS Number	22839-47-0 Y
3D model (Jmol)	Interactive image
ChEBI	CHEBI:2877 Y
ChEMBL	ChEMBL171679 Y
ChemSpider	118630 Y
DrugBank	DB00168 Y
ECHA InfoCard	100.041.132
E number	E951 (glazing agents, ...)
KEGG	C11045 Y
UNII	Z0H242BBR1 Y
InChI InChI=1S/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1 Y Key: IAOZJIPTCAWIRG-QWRGUYRKSA-N Y InChI=1/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1 Key: IAOZJIPTCAWIRG-QWRGUYRKBV
SMILES O=C(O)C[C@H](N)C(=O)N[C@H](C(=O)OC)Cc1ccccc1
Properties
Chemical formula	C14H18N2O5
Molar mass	294.31 g·mol−1
Density	1.347 g/cm3
Melting point	246 to 247 °C (475 to 477 °F; 519 to 520 K)
Boiling point	decomposes
Solubility in water	Sparingly soluble
Solubility	Slightly soluble in ethanol
Acidity (pKa)	4.5–6.0
Hazards
NFPA 704	1 1 0
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y  (what is YN ?)
Infobox references

Aspartame (APM; /ˈæspərteɪm/ or /əˈspɑːrteɪm/) is an artificial, non-saccharide sweetener used as a sugar substitute in some foods and beverages. In the European Union, it is codified as E951. Aspartame is a methyl ester of the aspartic acid/phenylalanine dipeptide. It was first sold under the brand name NutraSweet. It was first synthesized in 1965, and the patent expired in 1992.

The safety of aspartame has been the subject of several political and medical controversies, United States congressional hearings and Internet hoaxes since its initial approval for use in food products by the U.S. Food and Drug Administration (FDA) in 1981. The European Food Safety Authority concluded in its 2013 re-evaluation that aspartame and its breakdown products are safe for human consumption at current levels of exposure, corroborating other medical reviews. However, because its breakdown products include phenylalanine, aspartame must be avoided by people with the genetic condition phenylketonuria (PKU).