This is a list of fictional characters from DC Comics who are or have been enemies of Superman. It is notable that several of Superman's enemies are or have been foes of the Justice League of America as well.
In alphabetical order (with issue and date of first appearance):
According to writer Mark Evanier, Jack Kirby modeled Darkseid on actor Jack Palance.
In the modern era, Lex Luthor was re-envisioned as a wealthy CEO/scientist who hides his sociopathic tendencies behind a mask of philanthropy. Although beloved by the people of Metropolis for his many public works, Superman knows the truth. In the mainstream comic series, Luthor eventually manipulates his way to the U.S. Presidency, but is forcibly unseated from office by Superman and the Justice League.
In alphabetical order (with issue and date of first appearance):
Post-Crisis: Miguel Diaz and Ray Ryker were two physicists until a nuclear experiment goes wrong. Diaz is caught in an explosion that transfers his essence into the mechanical being, N.R.G.-X (Nuclear Radiation Generator Experimental). Confused and trying to escape, he confronts Superman encasing him in a steel shell. N.R.G.-X attempts to go after Ryker. Breaking free, Superman once again confronts N.R.G.-X who self-destructs in the process, reverting to a comatose Daiz.
Some characters originally conceived as heroes have come into conflict with Superman.
These are Superman villains created in other media, with no appearances in previous comics. Livewire, Mercy Graves, Non and Ursa subsequently made appearances in Superman comic books, and have been integrated into the mainstream continuity of the DC Universe.
A number of villains from the comic books have made an appearance, or appearances, in Superman related live-action media.