Duke of Uceda was a Spanish noble title created on 16 May 1610, by King Philip III of Spain, in favour of Cristóbal Gómez de Sandoval Rojas y de la Cerda. Cristóbal Gómez de Sandoval Rojas y de la Cerda was the son of Francisco Gómez de Sandoval, 1st Duke of Lerma, valido or de facto prime minister of King Philip III of Spain. In 1618 Cristobal replaced his father as valido after a plot, but was also overthrown 3 years later by Gaspar de Guzmán, Count-Duke of Olivares.
The title is named after the village of Uceda, Province of Guadalajara, which Cristóbal had bought a few years earlier from Diego Mejía de Obando, Count of Uceda.