Duke of Escalona is a Spanish noble title given by Henry IV of Castile in 1472 to Juan Pacheco, first Marquis of Villena.
The name Escalona refers to the village Escalona del Alberche, in the Province of Toledo.
The Dukes of Escalona remained an important family throughout the Spanish history.
Charles III of Spain made Juan Pacheco, 11th Duke-consort of Escalona a Grandee of Spain first class in 1750.
The Dukes of Escalona had many other titles, including : Marquis of Villena, Count of Xiquena, Count of San Esteban de Gormaz, Count of Castañeda, etc..