Duke Louis of Mecklenburg-Schwerin (German: Herzog Ludwig von Mecklenburg-Schwerin; 6 August 1725 – 12 September 1778) was heir to the Dukedom of Mecklenburg-Schwerin from 1756 to his death. He was also the father of the first Grand Duke of Mecklenburg-Schwerin Frederick Francis I

Louis was born at Grabow, Mecklenburg-Schwerin, third child and second son of Christian Ludwig II, Duke of Mecklenburg-Schwerin (1683–1756), (son of Frederick, Duke of Mecklenburg-Grabow and Landgravine Christine Wilhelmine of Hesse-Homburg) and his wife, Duchess Gustave Caroline of Mecklenburg-Strelitz (1694–1748), (daughter of Adolphus Frederick II, Duke of Mecklenburg-Strelitz and Duchess Marie of Mecklenburg-Güstrow).

After the death of the father in 1756, his brother Frederick succeed to the Dukedom. Since his brother died without any surviving issue he was appointed heir, but he died in 1778, and at the death of his brother in 1785 his son Frederick Francis, succeeded as the Duke of Mecklenburg-Schwerin who later became the Grand Duke of Mecklenburg-Schwerin.

Louis married 13 May 1755 at Schwerin to Princess Charlotte Sophie of Saxe-Coburg-Saalfeld (1731–1810), daughter of Francis Josias, Duke of Saxe-Coburg-Saalfeld, and his wife, Princess Anna Sophie of Schwarzburg-Rudolstadt.

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