Dry Creek or Dry Creek Drain (34°47′40″S 138°34′39″E / 34.79444°S 138.57750°E) is a seasonal stream in South Australia. In season it flows from its source near Yatala Vale in the Mount Lofty Ranges to the Barker Inlet of the Gulf St Vincent via a manufactured drain near Globe Derby Park. It passes through Modbury, Walkley Heights and Pooraka.
The suburb of Dry Creek and Dry Creek railway station are named after the stream.
Yatala Labour Prison was established in the 1850s next to Dry Creek and was alternately known at the time as the Dry Creek Prison or the Stockade. Dry Creek is mostly dry in summer and flows through a deep gully at the rear of the prison with outcrops of exposed pre-Cambrian rocks that were extensively quarried as part of prison activity.