Dry Creek is a stream located in Jefferson County, Missouri, United States. Its source is about 4.4 miles (7.1 km) west of De Soto, at 38°08′00″N 90°38′14″W / 38.1332°N 90.6373°W, and it empties into the Big River at 38°16′17″N 90°40′14″W / 38.2715°N 90.6705°W, near Morse Mill.
A 2006 survey by the Missouri Department of Natural Resources found the creek to be shallow and clear, with numerous fish in places.
This article incorporates public domain material from websites or documents of the United States Geological Survey.