Drue Pearce (born April 2, 1951) is an American businesswoman and politician.
Born in Fairfield, Illinois, Pearce received her bachelor's degree in biological science from Indiana University in 1973. She then received her master's degree in public administration from the John F. Kennedy School of Government in 1984. In 1989, Pearce went to the University of Virginia Darden School of Business. Pearce lived in Anchorage, Alaska and was in the banking and real estate business. From 1985 to 1989, Pearce served in the Alaska House of Representatives and was a Republican. Then, from 1989 to 2001, Pearce served in the Alaska State Senate and was president of the senate in 1995 and 1999. In 2001, Pearce resigned from the Alaska Senate to be the senior advisor of Alaska Affairs to the Secretary of the United States Department of Interior serving from 2001 to 2006. From 2006 to 2010, Pearce served as the administrator of the Office of the Federal Coordinator, Alaska Natural Gas Transportation Projects overseeing the construction of the proposed Alaska Natural Gas Pipeline.