Dominique Clos (25 May 1821, Sorèze – 19 August 1908) was a French physician and botanist.
He studied medicine and sciences in Toulouse and Paris, obtaining his medical degree in 1845 and his PhD in natural sciences in 1848. In 1853 he succeeded Alfred Moquin-Tandon as professor of botany at the University of Toulouse, maintaining this position until his retirement in 1889. At Toulouse, he made major contributions to its botanical garden and herbarium. From 1881 to 1908, he was a correspondent-member of the Académie des sciences.
He was the author of numerous works on descriptive botany, plant teratology, phytogeography and agricultural botany. As a taxonomist, he described many species from various plant families. Taxa with the specific epithet of closianus are named in his honor' an example being Astragalus closianus.