Domenico Manetti (1609–1663) was at Italian painter.
Manetti was born at Siena in 1609, and was probably a relation of Rutilio Manetti. He painted chiefly for the churches of Siena, but also produced historical subjects of an easel size. Lanzi particularly mentions one in the Casa Magnoni, representing the Baptism of Constantine. He died in 1663.
This article incorporates text from the article "MANETTI, Domenico" in Bryan's Dictionary of Painters and Engravers by Michael Bryan, edited by Robert Edmund Graves and Sir Walter Armstrong, an 1886–1889 publication now in the public domain.