Doctor Dré is best known for being the co-host of MTV's hip hop music specialty program Yo! MTV Raps with Ed Lover. The duo also starred in the 1993 film Who's the Man? Dré teamed up with Lover in the early 1990s to co-host a morning radio show during the re-launch of radio station Hot 97 (WQHT) in New York City.
Dré was a member of the hip hop group Original Concept, which released one album on Def Jam Recordings, Straight from the Basement of Kooley High; the group's best-known track was "Pump that Bass." He was also a former DJ for the Beastie Boys. Dré had his own urban clothing line called Bigga Stuff in the early 1990s, but it was never widely distributed. Dré and Ed Lover also recorded an album titled Back up off Me! that was released on Relativity Records. Dré and Ed Lover participated in the Comedy Central roast of comedian Denis Leary.
He guest-starred on The Fresh Prince of Bel-Air in the episode "Ill Will" as a figment of Will Smith's nightmare of bad doctors. He also appeared on an episode of the The People's Court with Judge Marilyn Milian as a witness for a talent director suing former colleagues of his. They won US$1,500, the full amount requested for the gig deposit.