The Dnipropetrovsk Regional Committee of the Communist Party of Ukraine, commonly referred to as the Dnipropetrovsk CPU obkom, was the position of highest authority in the Dnipropetrovsk Oblast, in the Ukrainian SSR of the Soviet Union. The position was created on February 27, 1932, and abolished in August 1991. The First Secretary was a de facto appointed position usually by the Central Committee of the Communist Party of Ukraine or the First Secretary of the Republic.