Ditolylguanidine

Ditolylguanidine

Clinical data
ATC code	none
Identifiers
IUPAC name 1,2-bis(2-methylphenyl)guanidine
CAS Number	97-39-2 Y
PubChem CID	7333
IUPHAR/BPS	6684
ChemSpider	7056 Y
ChEMBL	CHEMBL282433 Y
ECHA InfoCard	100.002.344
Chemical and physical data
Formula	C15H17N3
Molar mass	239.316 g/mol
3D model (JSmol)	Interactive image
SMILES N(=C(/Nc1ccccc1C)N)\c2ccccc2C
InChI InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18) Y Key:OPNUROKCUBTKLF-UHFFFAOYSA-N Y

Ditolylguanidine is a sigma receptor agonist. It is somewhat selective for sigma receptors, but non-selective between the two sigma receptor subtypes, binding to both σ1 and σ2 with equal affinity. It has neuroprotective and antidepressant effects, and potentiates the effects of NMDA antagonists.