"Disease" was released on September 30, 2002 as the first single from Matchbox Twenty's third album, More Than You Think You Are. It was co-written by Matchbox Twenty lead singer Rob Thomas and The Rolling Stones frontman Mick Jagger. The song peaked at #29 on the Billboard Hot 100. "Disease" was one of two songs written and presented to Mick Jagger, by Rob Thomas in which Jagger actually gives back the song, saying "it would sound better coming from you".

The video, directed by Phil Harder, starts with a man turning on his colorful boombox, then roller skating over a wide section of New York City, amid images of the band illuminated on moving billboards. During the second chorus, we see the band performing in a large outdoor roller-rink, complete with a disco ball. They are surrounded by a crowd dancing along, and to begin the 3rd chorus, Rob slides off the stage on all fours onto the dance floor past the crowd. At the end of the song, the roller skater shuts off his beat box and then proceeds up some stairs, presumably to his home.

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