Diffuse alveolar damage

Diffuse alveolar damage
Micrograph showing hyaline membranes, the key histologic feature of diffuse alveolar damage. H&E stain.
Classification and external resources
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Diffuse alveolar damage is a histological pattern in lung disease. It is seen in acute respiratory distress syndrome (ARDS),transfusion related acute lung injury (TRALI) and acute interstitial pneumonia (AIP).

Diffuse alveolar damage is associated primarily with ARDS and TRALI in adults, and hyaline membrane disease in neonates. It is most commonly associated with infection.

It is a common biopsy finding. Through histology, diffuse alveolar damage goes through several stages:

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