Diethylcathinone

Amfepramone

Clinical data
Trade names	Tenuate
AHFS/Drugs.com	Monograph
MedlinePlus	a682037
Pregnancy category	US: B (No risk in non-human studies)
Routes of administration	Oral
ATC code	A08AA03 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: Schedule IV DE: Anlage III (Prescription only) UK: Class C US: Schedule IV
Pharmacokinetic data
Biological half-life	4-6 hours (metabolites)
Excretion	Urine (>75%)
Identifiers
IUPAC name (RS)-2-diethylamino-1-phenylpropan-1-one
Synonyms	Diethylpropion
CAS Number	134-80-5 Y
PubChem CID	7029
IUPHAR/BPS	7161
DrugBank	DB00937 Y
ChemSpider	6762 Y
UNII	19V2PL39NG
KEGG	D07444 N
ChEBI	CHEBI:4530 Y
ChEMBL	CHEMBL1194666 N
ECHA InfoCard	100.001.836
Chemical and physical data
Formula	C13H19NO
Molar mass	205.30 g/mol
3D model (Jmol)	Interactive image
Chirality	Racemic mixture
SMILES O=C(c1ccccc1)C(N(CC)CC)C
InChI InChI=1S/C13H19NO/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12/h6-11H,4-5H2,1-3H3 Y Key:XXEPPPIWZFICOJ-UHFFFAOYSA-N Y
NY (what is this?)

Amfepramone (INN) is a stimulant drug of the phenethylamine, amphetamine, and cathinone classes that is used as an appetite suppressant. It is used in the short-term management of obesity, along with dietary and lifestyle changes. Amfepramone is most closely chemically related to the antidepressant and smoking cessation aid bupropion (previously called amfebutamone), which has also been developed as a weight-loss medicine when in a combination product with naltrexone.

Amfepramone itself lacks any affinity for the monoamine transporters and instead functions as a prodrug to ethcathinone. Ethcathinone (and therefore amfepramone as well) is a very weak dopaminergic and serotonergic, and is approximately 10x and 20x stronger on norepinephrine in comparison, respectively. As a result, ethcathinone and amfepramone can essentially be considered a member of the class of drugs known as norepinephrine releasing agents (NRAs).

Amfepramone is believed to have relatively low abuse potential. but recently there have been reports of teens and adults in the UK abusing this drug, known as "tombstones" to the abusers.

Amfepramone is classified as a Schedule IV controlled substance in the United States. It is also a Schedule IV controlled substance in Canada. In the UK Amfepramone is a class C drug and as a medicine, it is a Schedule 3 Controlled Drug which requires safe custody.