Diego Hurtado de Mendoza y de la Cerda (c. 1500 – Madrid, March 19, 1578), Duke of Francavilla and Prince of Melito, was a Spanish nobleman. He became viceroy of Aragon from 1553 or 1554-1564, Chairman of the Council of Italy in 1558, and viceroy of Catalonia. He was the grandson of Cardinal Mendoza and son of Diego Hurtado de Mendoza y Lemos and Ana de la Cerda y Castro.