Devils Elbow, Missouri is an unincorporated community in Pulaski County on historic U.S. Highway 66. It is situated on the Big Piney River and was named for a particularly bad place in the river known as a "devil of an elbow". It is about five miles (8 km) east of St. Robert.
A post office called Devils Elbow has been in operation since 1927. The community took its name from a nearby meander on the Big Piney River.
The major east-west route is Interstate 44; before that, the main highway was U.S. Route 66, which still exists as a scenic route through the area and passes through Devil's Elbow, St. Robert, Waynesville, Buckhorn, and Hazelgreen. Names for U.S. Route 66 vary - at different places, it is called Teardrop Road, Highway Z, Old Route 66, Historic Route 66, and Highway 17. State-posted signs mark most of the alignment of the road.