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Depomedrol

Methylprednisolone
Methylprednisolone.svg
Methylprednisolone.png
Clinical data
Trade names Medrol, Meprolone, others
AHFS/Drugs.com Monograph
MedlinePlus a682795
License data
Pregnancy
category
  • AU: A
  • US: C (Risk not ruled out)
Routes of
administration
IV, IM, by mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding 78%
Metabolism liver primarily, kidney, tissues; CYP450: 3A4 substrate
Biological half-life urine; Half-life: 18-26h (biological)
Identifiers
Synonyms (6α, 11β)-11,17,21-trihydroxy-6-methyl-pregna-1,4-diene-3,20-dione
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.001.343
Chemical and physical data
Formula C22H30O5
Molar mass 374.471 g/mol
3D model (Jmol)
  

Methylprednisolone, sold under the brand names Depo-Medrol and Solu-Medrol among others, is a corticosteroid medication used to suppress the immune system and decrease inflammation. Conditions in which it is used include skin diseases, rheumatic disorders, allergies, asthma, croup, COPD, certain cancers, multiple sclerosis, and as add-on therapy for tuberculosis. It is given by mouth or by injection into a vein, or muscle.

Serious side effects may include mental health problems and an increased risk of infection. Common side effects with long-term use include osteoporosis, cataracts, weakness, easy bruising, and yeast infections. Short-term use around the time of delivery is safe for the baby; however, long-term use during pregnancy may result in harm. Methylprednisolone is in the glucocorticoid family of medication.

Methylprednisolone was approved for medical use in 1955. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. Methylprednisolone is available as a generic medication. The wholesale cost in the developing world is about 3.81 to 9.35 USD per 500 mg vial. In the United States a course of treatment typically costs less than 25 USD.


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