Denmark competed in the Eurovision Song Contest 2010, held in Bærum,Norway in May 2010. The Danish broadcaster DR held the Dansk Melodi Grand Prix contest to select the country's entry for the contest, with the 2010 edition being held on 6 February 2010.

DR released details on the 2010 edition of the Dansk Melodi Grand Prix contest on 27 August 2009 – the format introduced in the 2009 Contest will remain in place – 10 songs would be chosen to compete in the contest, to be held on 6 February at the Gigantium in Aalborg. These ten songs would be made up of six songs selected by an internal jury from those submitted to DR from a public call for songs. They would be joined by four songs from artists invited by the broadcaster to compete. The show will be hosted by Felix Smith and Julie Berthelsen, and will be joined by Jørgen de Mylius and Keld Heick, who will provide support for the contestants and insight into the preparations needed for Eurovision.

Songwriters could submit their entries to DR until the deadline on 5 October. On that day DR revealed that they had received 562 entries for the contest. They also revealed that one of the entries came from DQ, who represented Denmark at the 2007 Contest, failing to qualify from the semi-final. 562 entries were received by DR, and the broadcaster revealing the 10 competing acts on 12 January 2010.

On 12 January DR announced the ten participants: seven acts from those submitted and three wildcards: Bryan Rice; Kaya Brüel; and girlband Sukkerchok.

Following media speculations, it was confirmed on 13 January by Jan Lagermand Lundme that Zindy Laursen had been invited to take part as a wildcard, performing the self-penned song "All About Me". She had, however, withdrawn from the competitions less than 24 hours before the participants were to be presented, and a back-up from the public call for songs, MariaMatilde Band's song "Panik!" was chosen as a replacement.

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